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Diphenhydramine Hydrochloride: 25 to 50 mg orally every 4 to 6 hours as needed-Maximum dose: 300 mg/day Parenteral: 10 to 50 mg deep IM or IV as needed Drug class: anticholinergic antiemetics Professional · Diphenhydramine Side Effects · Drug Interactions Usual Adult Dose For Extrapyramidal Reaction Oral: 25 to 50 mg orally 3 to 4 times a dayParenteral: 10 to 50 mg deep IM or IV as needed, and may increase to 100 mg if required-Maximum dose: 40 Usual Adult Dose For Insomnia Diphenhydramine Citrate: 76 mg orally once a day at bedtimeDiphenhydramine Hydrochloride: 50 mg orally once a day at bedtimeComment:-Patients shoul Usual Adult Dose For Motion Sickness Oral:-Prescription formulations: 25 to 50 mg orally 3 to 4 times a day, with the first dose given 30 minutes before exposure to motion and repeated Usual Adult Dose For Allergic Rhinitis Oral:Diphenhydramine Citrate: 38 to 76 mg orally every 4 to 6 hours as needed-Maximum dose: 456 mg/dayDiphenhydramine Hydrochloride: 25 to 50 mg or Usual Pediatric Dose For Allergic Rhinitis Prescription formulations:1 month and older:Oral: 12. 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